In such circumstances, it is usual to not only compare the means of the point in question on the two curves, but also to take into account the standard deviation (the grey region in the example above) - a difference of, say, 2° being considered insignificant if the SD were to be, say, ± 5°. In the example shown, the patient would appear to be just about within the normal range for peak swing phase knee flexion. So far so good...
A colleague here suggested an alternative method. Supposing we were
not to ensemble average the data from all these trials at all. We simply
measure the peak knee swing flexion in all the different trials individually
(rather laborious, I know, but let's assume we can do it) and derive a
mean and SD of these measurements in the two groups to be compared (patient/normative
dataset, or pre-op/post-op). So might have, for example:
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Of course, this might be a bit inconvenient because we would have to
set up a big database with all these conceivable measurements, and would
perhaps have to maintain the normative data in another big database in
case we ever want to introduce a new measurement. But I want you to consider
these two techniques purely from a mathematical standpoint.
Winter DA. Electromyogram recording, processing, and normalization: procedures and considerations. Journal of Human Muscle Performance. 1991;1:5-15.
Yang JF, Winter DA. Electromyographic amplitude normalization methods: improving their sensitivity as diagnostic tools in gait analysis. Arch Phys Med Rehabil. 1984;65:517-521
Jacobsen WC, Gabel RH, Brand RA. Surface vs fine-wire electrode ensemble-averaged signals during gait. J Electromyogr Kinesiol. 1995;5:37-44
Rice J.A., Silverman B.W., (1991) Estimating the mean
and covariance structure nonparametrically when the data are curves. Journal
of the
Royal Statistical Society, Bath. Vol 53 (1) pp. 233-243.
A. Kneip and Th. Gasser (1992). Statistical tools to analyze
data representing a sample of curves. Annals of Statistics 20 1266-1305.
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